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A panel of biomarkers (s CTX-I, u CTX-II, s OPG, s YKL-40, s COMP and s MMP-3) was assessed by ELISA.MRI images and conventional radiographs were scored according to the RA MRI score (RAMRIS) and the van der Heijde modified Sharp score (SHS), respectively.Longitudinal associations between biomarkers and MRI inflammation and disease activity score (DAS28) and association with the progression of damage were examined with adjustments for known predictors.

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